Surname Santa Irene (Santa Irene 
) , globally, is a rare cognomen. The last name Santa Irene is habitual in Latin America and the Caribbean, particularly Mexico, where it is a rare surname, Argentina, where it is a very rare surname, and Venezuela, where it is an extremely rare surname. More frequently, Santa Irene is the forename as well as the last name.
| VARIANT | COUNTRY |
|---|---|
| Santa Irene | Peru, Argentina, Dominican Republic, Mexico, Ecuador |